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Hepatic Glucose Production Mediated by Unsaturated Fatty Acids: The Role of G±q11 Protein.

Grant number: 13/26149-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2014
Effective date (End): November 22, 2018
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Dennys Esper Corrêa Cintra
Grantee:Vanessa de Oliveira
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated research grant:12/07129-6 - W3 and W9 fatty acids as inflammatory pathway blockers through GPR120 receptor: a multi-organic approach, AP.JP
Associated scholarship(s):16/05948-0 - Hepatic glucose production mediated by omega-3 fatty acids: the role of Galphaq/11 protein, BE.EP.DR


The type 2 diabetes mellitus prevalence is growing in Brazil and in the worldas a result of obesity, its most important predisposing factor. Chronic and low-gradeinflammation process induced by obesogenic condition interferes with glucose uptake,featuring the hyperglycemic state. The liver is one of the organs most affected by thisimbalance, however is independent of insulin for glucose uptake. Nevertheless, hepaticresistance to insulin signaling affects the blood glucose homeostasis controlled by theliver. On the other hand omega-3 (É3) and 9 (É9) fatty acids have been described asimportant anti-inflammatory agents. The GPR120 receptor recognizes É3 and 9 andactivates intracellular proteins to a specific way, such as ²-arrestin2, which diminishesthe inflammatory process by inhibiting immune response pathways such as Toll-likereceptors (TLR2/4) and tumoral necrosis factor (TNF), improving hepatic metabolicstate. However, an elegant work suggested that this potent observed improvement inglycemic control in obese animals could be due to an parallel inhibit inflammationmechanism. Biding with G protein, G±q11 subunit could play a major role in this aspect.G±q11 inhibited in lean or obese animals, even under the É3 or 9 fatty acids action,impaired the insulin signaling transduction. These fatty acids being potent activators ofGPR120, then it is possible that the prominent effects in relation to glucose uptake aremediated by this mechanism, independently of inflammatory remission. Therefore, theaim of this project is to determine the mechanism of action adopted by É3 and 9 fattyacids in the regulation of hepatic glucose metabolism.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Vanessa de. Produção hepática de glicose mediada por ácidos graxos ômega-3: o papel das proteínas Galfaq/11. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.

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