Scholarship 13/05382-9 - Terapia fotodinâmica, Síndrome de Down - BV FAPESP
Advanced search
Start date
Betweenand

Antimicrobial photodynamic therapy for treatment of periodontal disease in patients with Down Syndrome

Grant number: 13/05382-9
Support Opportunities:Scholarships in Brazil - Master
Start date until: May 01, 2014
End date until: March 31, 2015
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Carla Andreotti Damante
Grantee:Rafael Ferreira
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

Down Syndrome patients have a huge incidence of periodontal disease. One of the main goals of periodontal treatment is the periodontal health recovery through mechanical biofilm removal from corono-radicular surfaces. The success of this therapy depends on the elimination of pathogens present in the soft tissues. The photodynamic therapy has been used for endodontic and periodontic treatments. The aim of this study is to evaluate the clinical and microbiological effects of photodynamic therapy associated to scaling and root planning in Down Syndrome patients. 30 patients will be selected and randomly distributed in test group: scaling and root planning + photodynamic therapy and control group: scaling and root planning. The photodynamic therapy will be applied with a red laser (660nm) + Toluidine Blue O and will be repeated after 3, 7 and 14 days. For microbiologic analysis, samples of 6 deepest sites will be collected with absorbent paper cones and the quantification of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, Tannerella forshitia, Fusobacterium nucleatum will be done by RT-PCR. The microbiological parameters will be evaluated at baseline, 3 and 6 months after therapy. For statistical analysis multiple data will be evaluated by ANOVA complemented by Tukey or Kruskall-Wallis complemented by Dunn. Paired tests will be evaluated by Student's T-test or Mann-Whitney. The level of significance will be 5% (p<0.05). The present research has great importance in the scientific scenario because the proved additional benefits of photodynamic therapy will be used in Down Syndrome patients. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, RAFAEL; MICHEL, RAPHAELLA COELHO; AGUIAR GREGHI, SEBASTIAO LUIZ; RUBO DE RESENDE, MARIA LUCIA; PASSANEZI SANT'ANA, ADRIANA CAMPOS; DAMANTE, CARLA ANDREOTTI; RAGGHIANTI ZANGRANDO, MARIANA SCHUTZER. Prevention and Periodontal Treatment in Down Syndrome Patients: A Systematic Review. PLoS One, v. 11, n. 6, . (13/05382-9, 13/16607-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FERREIRA, Rafael. Antimicrobial photodynamic therapy on periodontal disease treatment in patients with Downs syndrome. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) Bauru.

Please report errors in scientific publications list using this form.