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Evaluation of therapeutic role of Angiotensin 1-7 in the prevention of the cardiovascular effects induced by thyroid hormone in Wistar rats

Grant number: 13/16348-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2014
Effective date (End): July 31, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Maria Luiza de Morais Barreto de Chaves
Grantee:Nathalia Senger
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


High levels of thyroid hormones (TH) are responsible for promoting changes in the cardiovascular system, which culminate in the development of cardiac arrhythmias and the installation of a hypertrophic process (Cappola et al., 2006). We have previously demonstrated that TH is able to promote cardiac hypertrophy and other cardiovascular manifestations through Renin-Angiotensin-System (RAS), especially due to the action of the peptide angiotensin II (Ang II), since the inhibition of its action blunted TH-induced cardiovascular changes. On the other hand, Angiotensin (1-7) (Ang 1-7), a peptide synthesized by RAS, promotes antiarrhythmic and anti-hypertrophic effects, and corresponds to an important regulatory arm in RAS. Thus, the aim of this study is to verify if Ang 1-7 may influence the cardiovascular effects induced by thyroid hormones, which are commonly observed in hyperthyroid patients. To perform that, male Wistar rats will receive daily intraperitoneal injections of T3 (20x physiological dose) for 21 and 28 days. Simultaneously, part of the animals will receive continuous infusion of Ang 1-7 (24¼g/Kg/hr) during the same experimental period. Morphological and funcional analyses of the heart, as well as the expression of proteins related to cardiac remodeling and RAS components will, be evaluated in hearts of animals of different groups.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SENGER, NATHALIA; MELO, MARCOS BARROUIN; DINIZ, GABRIELA PLACONA; CAMPAGNOLE-SANTOS, MARIA JOSE; SOUZA SANTOS, ROBSON AUGUSTO; BARRETO-CHAVES, MARIA LUIZA M.. Angiotensin-(1-7) reduces cardiac effects of thyroid hormone by GSK3 beta/NFATc3 signaling pathway. Clinical Science, v. 132, n. 11, p. 1117-1133, . (13/16348-6)
SENGER, NATHALIA; MELO, MARCOS BARROUIN; CAMPAGNOLE SANTOS, MARIA JOSE; SANTOS, ROBSON AUGUSTO; MORAIS BARRETO-CHAVES, MARIA LUIZA. Angiotensin-(1-7) Prevents cardiovascular changes induced by hyperthyroidism. FASEB JOURNAL, v. 31, p. 1-pg., . (13/16348-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SENGER, Nathalia. Evaluation of cardiac effects of angiotensin 1-7 in an animal model of hyperthyroidism.. 2015. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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