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Reduction of metabolic syndrome in Navarra-Spain (RESMENA) using a multidisciplinary approach and chrononutrition and nutrition education along dietary and psychological control

Grant number: 14/04902-1
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 01, 2014
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Carla Barbosa Nonino
Grantee:Carolina Nicoletti Ferreira Fino
Supervisor: J. Alfredo Martinez
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Universidad de Navarra, Spain  
Associated to the scholarship:12/03623-6 - Identification of genetic polymorphisms with impact on weight change and biochemical characteristics of obese individuals after gastric bypass Roux-Y, BP.DR


Obesity is considered to be one of the most severe public health problems. The positive energy balance, genetic, behavioral and environmental factors contribute significantly to the epidemic of obesity. Nutritional intervention such as hypocaloric diets may provide weight loss and improve the comorbities associated to metabolic syndrome. However, weight loss involves environmental, behavioral and genetic factors. Genetic variants may explain the predisposition to obesity, the facility of weight loss or resistance to it after dietary interventions. Obesity has been linked to changes in the pattern of DNA methylation in young adults, but little is known about the effect of interventions for weight loss in epigenetic markers. This study aims to investigate the possible modifications in the epigenetic patterns of genes related to obesity, adipogenesis and inflammation in peripheral white blood cells in a follow-up of the Metabolic Syndrome Reduction in Navarra (RESMENA) project population after following 8 weeks an energy-restricted dietary program. The blood sample will be collected from 40 obese patients for biochemical analysis (lipid profile and glucose) and DNA methylation patterns with the Infinium Human Methylation 450K bead chip technology (Illumina, San Diego, CA). Anthropometric, body composition measurements (by bioimpedance) and dietary and features also will be evaluated. Data will be analyzed statistically using the SPSS 13.0 software. A P value <0.05 will be considered to be statistically significant. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA NICOLETTI, CAROLINA; BARBOSA NONINO, CARLA; PARENTI DE OLIVEIRA, BRUNO AFFONSO; DE SOUZA PINHEL, MARCELA AUGUSTA; LUISA MANSEGO, MARIA; IGNACIO MILAGRO, FERMIN; ANGELES ZULET, MARIA; ALFREDO MARTINEZ, JOSE. DNA Methylation and Hydroxymethylation Levels in Relation to Two Weight Loss Strategies: Energy-Restricted Diet or Bariatric Surgery. OBESITY SURGERY, v. 26, n. 3, p. 603-611, . (13/08916-4, 14/04902-1)

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