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Synthesis and biological evaluation of Brevipolide a and related compounds

Grant number: 13/16174-8
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2014
Effective date (End): March 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Acordo de Cooperação: NSF - American Universities (Chemistry)
Principal Investigator:Ronaldo Aloise Pilli
Grantee:Franco Della Felice
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action, AP.TEM

Abstract

The research proposal aims the total synthesis of brevipolide A (1), a polyketide isolated from Hyptis breivpes, based on a modular approach involving the coupling of fragments I-III. The lack of total synthesis and our interest to evaluate its cytotoxic actiivity as well as the inhibition of protein phosphatases by the natural product and related compounds support this research proposal. (AU)

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