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The role of the IL-6 on the insulin clearance in obese mice submitted to acute exercise

Grant number: 13/21283-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2014
Effective date (End): February 28, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Antonio Carlos Boschiero
Grantee:Mirian Ayumi Kurauti
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:11/09012-6 - Molecular mechanisms involved in the dysfunction and death of pancreatic beta cells in Diabetes Mellitus: strategies for the prevention of islet dysfunction and for islet mass recuperation in different cellular and animal models, AP.TEM


Obesity is a public health problem. Obese individuals are more prone to developing chronic diseases such as Hypertension, Arteriosclerosis and Diabetes Mellitus type 2 (DM2). High-fatty diet is a robust model for the study of obesity and physical exercise is recommended for the treatment and prevention of this pathology. The acute exercise increase the plasmatic concentrations of interleukin-6 (IL-6) and obese individuals also presented elevated concentrations of this cytokine, however a chronic way. Hyperinsulinemia is also increased in obese animals and the physical exercise reverses this processes. We hypothesized that this response be mediated by modulations of the hepatic insulin clearance and the responsible molecule for the cross-talk between muscle and liver during the exercise be the secretion of IL-6 from muscle. For these propose, we will separate the animals in five groups: control (C), obese (O), obese treated with IL-6 (O+IL6), exercised obese (EO), exercised obese treated with IL-6 inhibitor (EO-IL6). Ten days before submit to acute exercise, will be evaluated the maximums oxygen consume (VO2 máx), glucose tolerance test (GTT), insulin tolerance test (ITT) and insulin clearance. After to acute exercise, we will evaluate the glycemic control with the cited tests, besides biochemistry parameters plasmatic, and gene (Real-Time RT-PCR) and protein expression (Western-Blot).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KURAUTI, MIRIAN A.; COSTA-JUNIOR, JOSE M.; FERREIRA, SANDRA M.; DOS SANTOS, GUSTAVO J.; PROTZEK, ANDRE O. P.; NARDELLI, TARLLIZA R.; DE REZENDE, LUIZ F.; BOSCHERO, ANTONIO C.. Acute exercise restores insulin clearance in diet-induced obese mice. Journal of Endocrinology, v. 229, n. 3, p. 221-232, . (13/21283-0, 13/07607-8)

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