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Profile of extracellular vesicles miRNA in the neuronal differentiation of murine embryonic stem cells

Grant number: 13/22078-1
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2014
Effective date (End): April 30, 2017
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal researcher:Marilene Hohmuth Lopes
Grantee:Lilian Cruz
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):15/25756-6 - Extracellular vesicles function during neural differentiation of mouse embryonic stem cells, BE.EP.DD


Within each such microenvironment, stem cells process and sense multiple signals, which can exert influences that collectively regulate cell fate and function in a time-spatial manner. In this context, the stem cells can exert their biologic role transferring genetic information and altering the genetic expression of target cells through extracellular vesicles. MicroRNAs (miRNAs), a class of small non coding RNAs, can be found in those extracellular vesicles and considered effective molecules in the control of development and differentiation by key genes regulation in time specific. Many miRNA are capable of regulating neurogenesis by promoting neuronal differentiation or supporting neural progenitor cells maintenance avoiding their differentiation. In this sense, the pluripotent cell commitment to a neural fate is supposed to be regulated by specific miRNA released by secreted extracellular vesicles. Therefore, the study purposes to analyze the profile of miRNA present in extracellular vesicles during neuronal differentiation of murine embryonic stem cells and identify the possible target gene regulated by them to disclose the mechanism of neuronal specific fate commitment. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CRUZ, LILIAN; AREVALO ROMERO, JENNY ANDREA; PRADO, MARIANA BRANDAO; SANTOS, TIAGO G.; LOPES, MARILENE HOHMUTH. Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells. STEM CELL REVIEWS AND REPORTS, v. 14, n. 2, p. 262-276, . (14/17385-5, 13/22078-1, 11/13906-2)
CRUZ, LILIAN; ROMERO, JENNY A. A.; IGLESIA, REBECA P.; LOPES, MARILENE H.. Extracellular Vesicles: Decoding a New Language for Cellular Communication in Early Embryonic Development. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 6, . (17/20271-0, 14/17385-5, 13/19860-0, 11/13906-2, 13/22078-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CRUZ, Lilian. Intracellular and extracellular vesicles miRNAs profile during neural differentiation of pluripotent stem cells.. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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