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Osseointegration of titanium implants installed without primary stability in diabetic rats: influence of association fibrin adhesive/tranexamic acid

Grant number: 13/23308-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2014
Effective date (End): March 31, 2015
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Maria Cristina Rosifini Alves Rezende
Grantee:Marina Tolomei Sandoval Cury
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


When implants are installed immediately after tooth extraction may occur anchoring primary and decreased delay and / or impairment of the osseointegration process. This occurs because of the large interface between the surrounding walls of the socket and the surface of the implant. The purpose of this study is the histologic evaluation of the bone healing in diabetic rat around implants associated with fibrin adhesive/ tranexamic acid. Will be made 80 implants of titanium ASTM F67 (Grade 4), with dimensions of 2.1 x 2.8mm, CNC machined around STAR ® model SR-20RII, with power of 2.2 kW. The implants will be divided (n=40) into Group A (health rat) and Group B(diabetic rat). These groups will be divided again into GI (machined), GII (machined/ fibrin adhesive), GIII (machined/tranexamic acid) and GIV (machined/ fibrin adhesive/tranexamic acid). Following are implanted in femurs of 80 male rats (250 grams), which will be anesthetized (Xylazine/Ketamine) and shaved on its hind legs straight. After incision, divulsion, access to the bone bed and punching over milling (twist drill with 2.5 mm in diameter) under irrigation with saline, the surgical beds will be filled with the material to each group and the implants installed. Following is sutured (4.0 wire). The animals will be sacrificed at 60 days postoperatively. The pieces will be processed in MMA (Stevenel's blue/Alizarin red S).

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