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Analysis and Development of Protocols in Bioinformatics for Epigenetic Studies

Grant number: 13/24801-2
Support type:Scholarships in Brazil - Master
Effective date (Start): April 01, 2014
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Iscia Teresinha Lopes Cendes
Grantee:Wélliton de Souza
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:11/50680-2 - Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools, AP.TEM


Epigenetic changes are those that occur during cellular division, modifying gene expression without changes on the DNA sequence. They are involved in gene silencing, tissue differentiation and in molecular mechanisms of a number of phenotypes. DNA methylation, an epigenetic modification that changes chromatin, has been studied extensively in various normal and pathologic biological processes. With the advancement of technologies and protocols for DNA sequencing, it is now possible to perform analysis to determine methylation profiles and their association with phenotypes of interest. This project will add the epigenetics perspective to ongoing studies on epilepsies through the development of analytical methodologies and high-performance computational tools. We will use current statistical approaches and up-to-date bioinformatics protocol to analyze bisulfite-treated DNA data. This will allow us to determine methylation profiles and estimate their association to the epilepsy phenotypes on animal models.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, WELLITON; CARVALHO, BENILTON DE SA; LOPES-CENDES, ISCIA. Rqc: A Bioconductor Package for Quality Control of High-Throughput Sequencing Data. JOURNAL OF STATISTICAL SOFTWARE, v. 87, n. CN2, p. 1-14, . (13/24801-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Wélliton de. Analysis and development of bioinformatics protocols for epigenetics studies. 2016. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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