Scholarship 13/26467-2 - Cirurgia bucal, Dor - BV FAPESP
Advanced search
Start date
Betweenand

Comparison of the clinical efficacy of naproxen, associated or not with esomeprazol, in the control of pain, swelling and trismus in lower third molar removal

Grant number: 13/26467-2
Support Opportunities:Scholarships in Brazil - Master
Start date until: April 01, 2014
End date until: March 31, 2016
Field of knowledge:Biological Sciences - Pharmacology - Clinical Pharmacology
Principal Investigator:Carlos Ferreira dos Santos
Grantee:Giovana Maria Weckwerth
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

The control of pain, swelling and trismus in patients undergoing oral and maxillofacial surgery is frequently performed through the administration of non-steroidal antiinflammatory drugs (NSAIDS). Studies have shown that NSAIDS exert their therapeutic effect by the inhibition of cyclooxigenases (COX) 1 and 2, which determines the inhibition of prostaglandins production whose effects potentiate the action of many inflammatory mediators. The present study aims to evaluate in a double blind, randomized and cross over manner the clinical efficacy of naproxen (500 mg) and naproxen in association with esomeprazol (500 mg and 20 mg), both administered by oral route every 12 h during 4 days, in 50 patients aged 18 years or older that require removal of both lower third molars symmetrically positioned. The following parameters will be analyzed: 1) subjective postoperative pain evaluation, with the aid of a visual analogue scale, 2) mouth opening before the surgery, on the 2nd and 7th postoperative days (moment of suture removal), 3) beginning and duration of the surgery after anesthetic administration, 4) incidence, type and severity of adverse reactions, 5) total amount of rescue analgesic medication (paracetamol), 6) facial swelling measured on the 2nd and 7th postoperative days (in comparison with the measurements before the surgery). The comparative analyses of the data along with the application of the adequate statistical tests will provide the basis for an evaluation of the clinical efficacy of both NSAIDS. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
WECKWERTH, Giovana Maria. Comparison of the clinical efficacy of naproxen, associated or not with esomeprazole, in the control of pain, swelling and trismus in lower third molar removal. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) Bauru.

Please report errors in scientific publications list using this form.