Advanced search
Start date

Analysis of fresh cells of the periodontal ligament and the biomodificador effect aiming the regeneration of the periodontal tissue

Grant number: 13/25990-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Mario Taba Junior
Grantee:Carla de Oliveira Pires da Silva
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Periodontitis is a multifactorial chronic inflammatory disease highly prevalent in the population, which affects the supporting tissues of the teeth generating sequels difficult to solve even with the most modern regenerative techniques. Cell therapy seems to be a promising alternative and undifferentiated cells of the periodontal ligament (PDLSC) has shown great therapeutic potential. However, PDLSC require appropriate stimuli biomodificadores for the differentiation to occur. The Enamel Matrix Derivative (EMD) is a type of biomodificador that promotes periodontal regeneration through formation of new cementum. Despite being used clinically, its association with fresh periodontal ligament cells has not been explored. The objective of this study is to evaluate the regenerative potential of cells removed from the periodontal ligament and identify the feasibility of association with the EMD through the analysis of gene expression and protein. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Carla de Oliveira Pires da. Evaluation of the tissue viability of fresh periodontal ligament under the influence of enamel matrix proteins and their angiogenic potential. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

Please report errors in scientific publications list by writing to: