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Baccharis trimera (Less.) DC. essential oil: genotoxicity, mutagenicity and metabolism studies

Grant number: 13/13196-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2014
Effective date (End): July 31, 2017
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Ana Lúcia Tasca Gois Ruiz
Grantee:Adriana Della Torre
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


We live in an aerobic environment so all organisms stay continuously and inevitably exposed to reactive oxygen and/or nitrogen species, which could react with lipid from membranes, intracellular proteins and DNA, damaging these structures and therefore are related to the genesis of a number of chronic diseases, such as cancer. On the other hand, many chronic parasitic diseases such as schistosomiasis, are classified as neglected tropical diseases, possessing just few therapeutic option which results in increasing emergence of resistant strains. Thus, natural products constitute an important source of therapeutic alternatives for parasitosis and chronic diseases treatments, besides can also be used in preventing various diseases through different mechanisms of action, such as immunomodulation and antioxidant capacity. "Carqueja", Baccharis trimera (Less.) DC. (Asteraceae), is a native species from tropical regions and has been widely used in folk medicine as anti-inflammatory, to treat worms, liver and kidney problems as well as stomach and intestinal disorders. Recent studies of B. trimera essential oil (EO) demonstrated potential schistosomicidal activity on adult worms of Schistosoma mansoni (BH strain). Since B. trimera EO presents potential medicinal uses, this project aims to further evaluate the antimutagenic activity / mutagenic in vitro EO and its major compounds using the comet assay and micronucleus induction model, with optical microscopy and flow cytometry analysis, associated with EO phytochemical study and preliminary evaluation of in vitro metabolism, in order to correlate chemical composition with the observed activities. Thus, this study will contribute to the establishment of the safety of the medicinal use of B. trimera EO.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOBREIRO, MARIANA ALVES; DELLA TORRE, ADRIANA; DE ARAUJO, MARIA ELISA MELO BRANCO; CANELLA, PAULA RENATA BUENO CAMPOS; DE CARVALHO, JOAO ERNESTO; CARVALHO, PATRICIA DE OLIVEIRA; RUIZ, ANA LUCIA TASCA GOIS. Enzymatic Hydrolysis of Rutin: Evaluation of Kinetic Parameters and Anti-Proliferative, Mutagenic and Anti-Mutagenic Effects. LIFE-BASEL, v. 13, n. 2, p. 14-pg., . (11/12394-8, 11/03540-0, 11/01114-4, 09/09224-3, 13/13196-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TORRE, Adriana Della. Baccharis trimera (Less.) DC. essential oil: genotoxicity, mutagenicity and metabolism studies. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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