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Evaluation of the pre-osteoblasts response cultured on scaffolds of polyhydroxybutyrate functionalized with hydroxyapatite and osteogenic peptide

Grant number: 13/23873-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2014
Effective date (End): August 31, 2015
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Joni Augusto Cirelli
Grantee:Mariana Aline Cominotte
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


With the evolution of the cell biology and tissue engineering areas new materials have been studied aiming their application in the treatment of bone defects. The polyhydroxybutyrate (PHB) is a thermoplastic polymer that has several important features to be successfully used as a restorative tissue such as its ability to allow cell proliferation and migration. The Rapid Prototyping (RP) is an advanced computerized method that allows the fabrication of 3D structures (scaffolds) of PHB with macro and microstructural characteristics that promote and enhance its ability to allow cell proliferation. These pieces when functionalized with hydroxyapatite or an osteogenic peptide may become potential candidates to stimulate bone formation on certain defects. The objective of this study is to evaluate in vitro the response of pre-osteoblasts cultured on scaffolds of PHB functionalized with hydroxyapatite associated or not with osteogenic peptide. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COMINOTTE, Mariana Aline. Physico-chemical and biological analyzes of different scaffolds based on polyhydroxybutyrate and polyhydroxybutyrate-co-valerate. 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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