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Phenotypic and genotypic profile of Candida spp. strains of candidemia episodes in the Faculty of Medicine of Ribeirão Preto Hospital - FMRP-USP

Grant number: 13/23485-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2014
Effective date (End): February 28, 2017
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Márcia Eliana da Silva Ferreira
Grantee:Heliara Maria Spina Canela
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Since the 80s, the number of patients affected by invasive infections caused by Candida species has been increasing due the increase of immunocompromised patients, invasive procedures, and use of broad-spectrum antibiotics. These yeasts, which are part of the human microbiota, take advantage of imbalances on the host to cause infections, which can be superficial or invasive. The invasive infections, known as candidemias, can present a mortality rate up to 50% and are mainly caused by Candida albicans, C. parapsilosis, C. glabrata and C. tropicalis. Their prevalence varies between countries and each species has special characteristics, which makes necessary their identification. In addition to the identification, characterization of isolates in epidemiological studies is relevant and can be done using the antifungal susceptibility tests and phenotypic and genotypic tests. In this context, this project purposes to characterize, phenotypically and genotypically, isolates from candidemia episodes occurred on clinics hospital of FMRP, as well as analyze their sensitivity to the antifungal agents used in the treatment of candidemia. For this, tests will be done to detect the presence of proteinase, phospholipase and hemolysin; MLST, PFGE and MLP genotyping; and disk diffusion susceptibility test and broth microdilution test according to CLSI guidelines. It is expected; therefore, contribute to this disease epidemiology on the hospital and in Brazil.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CANELA, HELIARA MARIA SPINA; CARDOSO, BARBARA; FRAZAO, MILIANE RODRIGUES; FALCAO, JULIANA PFRIMER; VITALI, LUCIA HELENA; MARTINEZ, ROBERTO; DA SILVA FERREIRA, MARCIA ELIANA. Genetic diversity assessed using PFGE, MLP and MLST in Candida spp. candidemia isolates obtained from a Brazilian hospital. Brazilian Journal of Microbiology, v. 52, n. 2, . (14/10628-0, 13/23485-0)
SPINA CANELA, HELIARA MARIA; CARDOSO, BARBARA; VITALI, LUCIA HELENA; COELHO, HARNOLDO COLARES; MARTINEZ, ROBERTO; FERREIRA, MARCIA ELIANA DA SILVA. Prevalence, virulence factors and antifungal susceptibility of Candida spp. isolated from bloodstream infections in a tertiary care hospital in Brazil. MYCOSES, v. 61, n. 1, p. 11-21, . (13/23485-0, 14/10628-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CANELA, Heliara Maria Spina. Phenotypic and genotypic profile of Candida spp. strains in candidemia episodes of Hospital das Clínicas of Faculdade de Medicina de Ribeirão Preto - FMRP-USP. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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