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A study of the signaling pathways induced by RBP4 in macrophages and dendritic cells in obesity-induced insulin resistance

Grant number: 14/02218-6
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 01, 2014
Effective date (End): April 30, 2015
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Niels Olsen Saraiva Câmara
Grantee:Angela Castoldi
Supervisor: Barbara Barken Kahn
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Harvard University, Boston, United States  
Associated to the scholarship:11/15682-4 - Sepsis and Obesity: study of the relationship between obesity and immune regulation in an experimental model of sepsis, BP.DR


A major cause of type 2 diabetes (T2D) is impaired insulin action in adipose tissue, skeletal muscle and liver. RBP4 levels are elevated in many insulin-resistant states in mice and humans and the manipulation of the levels of RBP4 in the serum affects insulin responses. Emerging evidence suggests a possible role for pro-inflammatory pathways in RBP4-induced insulin resistance. Obesity is a state of chronic, low-grade inflammation, and macrophages and dendritic cells are thought to play an important role in maintaining this state. The role of RBP4 in macrophage and dendritic cell signaling pathways remains unclear. In this study, we pretend show the effect of RBP4 on the activation of this cells and the role of RBP4-induced pathways in the development of obesity. It is extremely important that we know the signaling pathways activated in adipose tissue macrophages and dendritic cells during obesity and insulin resistance in order to create new methods for therapeutic intervention in these pathways which may contribute to reduce the effects of inflammation in the development of insulin resistance during obesity. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEE, JENNIFER; MORAES-VIEIRA, PEDRO M.; CASTOLDI, ANGELA; ARYAL, PRATIK; YEE, ERIC U.; VICKERS, CHRISTOPHER; PARNAS, OREN; DONALDSON, CYNTHIA J.; SAGHATELIAN, ALAN; KAHN, BARBARA B.. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. Journal of Biological Chemistry, v. 291, n. 42, p. 22207-22217, . (11/15682-4, 14/02218-6)
MORAES-VIEIRA, PEDRO M.; CASTOLDI, ANGELA; ARYAL, PRATIK; WELLENSTEIN, KERRY; PERONI, ODILE D.; KAHN, BARBARA B.. Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance. Diabetes, v. 65, n. 5, p. 1317-1327, . (14/02218-6)
CASTOLDI, ANGELA; DE AGUIAR, CRISTHIANE FAVERO; MORAES-VIEIRA, PEDRO MANOEL; SARAIVA CAMARA, NIELS OLSEN. They Must Hold Tight: Junction Proteins, Microbiota And Immunity In Intestinal Mucosa. CURRENT PROTEIN & PEPTIDE SCIENCE, v. 16, n. 7, p. 655-671, . (14/10828-9, 12/02270-2, 12/16794-3, 14/02218-6, 11/15682-4)
MORAES-VIEIRA, PEDRO M.; YORE, MARK M.; SONTHEIMER-PHELPS, ALEXANDRA; CASTOLDI, ANGELA; NORSEEN, JULIE; ARYAL, PRATIK; SJOEDIN, KOTRYNA SIMONYTE; KAHN, BARBARA B.. Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll -like receptors 2 and 4. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 117, n. 49, p. 31309-31318, . (15/15626-8, 14/02218-6)
ZEMANY, LAURA; BHANOT, SANJAY; PERONI, ODILE D.; MURRAY, SUSAN F.; MORAES-VIEIRA, PEDRO M.; CASTOLDI, ANGELA; MANCHEM, PRASAD; GUO, SHULING; MONIA, BRETT P.; KAHN, BARBARA B.. Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice. Diabetes, v. 64, n. 5, p. 1603-1614, . (14/02218-6)

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