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Subtotal laparoscopic hysterectomy x total laparoscopic hysterectomy for imediate and late postoperative outcomes: a randomized controlled trial

Grant number: 13/25956-0
Support Opportunities:Scholarships abroad - Research
Effective date (Start): May 10, 2014
Effective date (End): May 09, 2015
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Luiz Gustavo Oliveira Brito
Grantee:Luiz Gustavo Oliveira Brito
Host Investigator: Jon Ivar Einarsson
Host Institution: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil
Research place: Harvard University, Boston, United States  


Hysterectomy is the most performed gynecological surgery in the world, and several minimally invasive approaches has been developed to improve postoperative period of women, such as laparoscopy. Preservation of the uterine cervix during hysterectomy (subtotal or supracervical hysterectomy) is a controversial step regarding its interference on sexual function or genital prolapse after surgery. There are few studies comparing subtotal hysterectomy versus total hysterectomy, and no study comparing these approaches laparoscopically. The aim of this research is to realize a study with women scheduled for hysterectomy due to benign gynecological conditions that will remove the cervix or not during surgery. It is proposed a randomized, factorial, controlled trial, single-blinded for the postoperative research evaluator of patients from Brigham & Womens Hospital, one the biggest minimally invasive surgical centers in the world, with enrollment starting January 2014. Primary endpoint is precocious return to activities. Secondary endpoints are: operative time, blood loss, intraoperative complications, postoperative pain, quality of life, sexual function, presence of genital prolapse, urinary symptoms. It is expected that with these results, we may be able to guide gynecological surgeons to council their patients if there is (or not) any benefits to remove the uterine cervix during hysterectomy. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRITO, LUIZ GUSTAVO OLIVEIRA; COHEN, SARAH LAUREN; TUSHEVA, OLGA; KOHLI, NEERAJ; MORSE, ABRAHAM; GOGGINS, EMILY ROSE; EINARSSON, JON IVAR. Resultados cirúrgicos de uma abordagem cirúrgica combinada para a correção do prolapso apical. Revista Brasileira de Ginecologia e Obstetrícia, v. 38, n. 8, p. 405-411, . (13/25956-0)
POUWELS, NIECK S. A.; BRITO, LUIZ G. O.; EINARSSON, JON I.; GOGGINS, EMILY R.; WANG, KAREN C.; COHEN, SARAH L.. Cervix removal at the time of hysterectomy: factors affecting patients' choice and effect on subsequent sexual function. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v. 195, p. 67-71, . (13/25956-0)
BRITO, LUIZ GUSTAVO O.; COHEN, SARAH L.; GOGGINS, EMILY R.; WANG, KAREN C.; EINARSSON, JON I.. Essure Surgical Removal and Subsequent Symptom Resolution: Case Series and Follow-Up Survey. JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, v. 22, n. 5, p. 910-913, . (13/25956-0)

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