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Syntheis and evaluation of the pharmacological potential of Pyrazolones and Pyrazolidinones, from Morita-Baylis-Hillman adducts

Grant number: 13/24386-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2014
Effective date (End): May 01, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Fernando Antonio Santos Coelho
Grantee:Laís Vaz Acconcia
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):14/26027-5 - Bi-functional catalyst for the Morita-Baylis-Hillman: new applications, BE.EP.IC

Abstract

This undergraduated research project aim at synthezising new pyrazolidinones and pyrazolones, using a methodology previously developed in our laboratory. Morita-Baylis-Hillman adducts are used as platform for the construction of new heterocycle compounds. The new pyrazolidines and pyrazolones synthezised in this project will be incorporated in a library of compounds screened against inflammationd and diseases caused by parasites, such as leishmaniosis (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORREIA, JOSE TIAGO M.; ACCONCIA, LAIS V.; COELHO, FERNANDO. Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, n. 11, p. 1972-1976, . (13/24386-5, 13/10449-5, 12/21809-0, 13/07600-3)
ZEOLY, LUCAS A.; ACCONCIA, LAIS V.; RODRIGUES JR, MANOEL T.; SANTOS, HUGO; CORMANICH, RODRIGO A.; PANIAGUA, JUAN C.; MOYANO, ALBERT; COELHO, FERNANDO. One-pot organocatalyzed synthesis of tricyclic indolizines. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 21, n. 17, p. 15-pg., . (13/07600-3, 14/26027-5, 13/24386-5, 18/02611-0, 15/00975-7, 15/09205-0)
CORREIA, JOSE TIAGO M.; ACCONCIA, LAIS V.; COELHO, FERNANDO. Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2016, n. 11, p. 5-pg., . (12/21809-0, 13/24386-5, 13/07600-3, 13/10449-5)

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