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Effect of low-level laser therapy on the functional aspects in an experimental model of skeletal muscle trauma in diabetic rats

Grant number: 13/22041-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2014
Effective date (End): January 31, 2015
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Rodrigo Leal de Paiva Carvalho
Grantee:Jéssica de Souza Ribeiro
Host Institution: Centro de Ciências da Saúde. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil


Aerobic exercise and resistance have been prescribed for the prevention and treatment of patients with Diabetes Mellitus (DM) due to the improvement in glucose control and reduction of other risk factors. Traumatic muscle injuries are directly related to physical activity, which may cause a functional loss in varying degrees. Different types of therapies, pharmacological and non-pharmacological approaches have been used in the treatment and recovery of musculoskeletal injuries, such as anti-inflammatory drugs and low-level laser therapy. However, the process of functional recovery after injury in the course of diabetes remains unknown. The aim of this work is to study the functional aspects of recovery of skeletal muscle trauma induced in Wistar rats with diabetes compared to no diabetics. A single trauma will be performed employing a mini guillotine, comprising a block weight of 200g that will drop from 20cm on the right posterior limb. Induction of diabetes is by intraperitoneal administration of streptozotocin (STZ) at a concentration of 50 mg/kg body weight. Irradiation with Laser will be held at only one point in the area of trauma, after injury protocol, with a dose of 3 J per the 30s. Diclofenac is applied one hour after injury protocol at a dose of 6.11 mg g -1 (milligram gram) topically. Functional assessment will be conducted through the walking track analysis will perform at 12, 24, and 48h after trauma. (AU)

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