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Pathogenicity evaluation of mutant strains from Salmonella Gallinarum biovar Gallinarum for genes related to metabolism naturally defectives in Salmonella Gallinarum biovar Pullorum

Grant number: 13/22920-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2014
Effective date (End): July 31, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal researcher:Angelo Berchieri Junior
Grantee:Diego Felipe Alves Batista
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Salmonella enterica subsp. enterica serovar Gallinarum biovar Gallinarum (S. Gallinarum) is the biologic agent of fowl typhoid, a grave disease that takes place in birds of any age though it is more common in adults. Salmonella enterica subsp. enterica serovar Gallinarum biovar Pullorum (S. Pullorum) is the pathogen causative of pullorum disease, a systemic illness that occurs mainly in young birds. The bacterium may induce a carrier state in some of them and is able to be transmitted vertically to progeny. Both bacteria are genetically and phenotypically similar, but showing distinct pathogenicity and epidemiology. It is believed that their ability to differentially modulate host immune response associated with some pathogenicity island two (SPI-2) intrinsic factors would be linked to differences observed in pathogenesis. During to our master's degree study, when we compared these bacteria whole genomes, we did not observe any structural modification or divergence in virulence genes content. Nevertheless, it was seen in metabolism genes. Some studies have shown that different bacterial metabolisms lead to distinct regulation of their virulence genes. Here, we aim to build and assess S. Gallinarum mutant strains defective to some metabolism genes which are naturally inactivated at S. Pullorum genome. We will still assess the capability of them to cause mortality, induce carrier state in chickens infected at 5º day-old and the sort of immune response which will be triggered at the spleen and cecal tonsils during to the course of infection.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES BATISTA, DIEGO FELIPE; DE FREITAS NETO, OLIVEIRO CAETANO; DE ALMEIDA, ADRIANA MARIA; MABONI, GRAZIELI; DE CARVALHO, TATIANE FURTADO; DE CARVALHO, THAYNARA PARENTE; BARROW, PAUL ANDREW; BERCHIERI JUNIOR, ANGELO. Evaluation of pathogenicity of Salmonella Gallinarum strains harbouring deletions in genes whose orthologues are conserved pseudogenes in S. Pullorum. PLoS One, v. 13, n. 7 JUL 20 2018. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BATISTA, Diego Felipe Alves. Evaluation on the pathogenicity of genetically engineered Salmonella Gallinarum biovar Gallinarum strains harbouring mutations in metabolism-related genes naturally inactivated in S. Gallinarum biovar Pullorum genomes. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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