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Relationship of birth weight and weight for gestational rate with ovarian reserve in women older than 30 years: cross-sectional study nested in a women's cohort

Grant number: 13/16118-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): January 01, 2014
Effective date (End): December 31, 2015
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Paula Andrea de Albuquerque Salles Navarro
Grantee:Maria Lucia dos Santos Lima
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Introduction. Intrauterine life condition may have a direct or indirect impact on the reproductive future of women. However, to date, no studies are available evaluating the relationship between birth weight and ovarian reserve in the fourth decade of life. The serum levels of anti-mullerian hormone (AMH) are directly related to follicular reserve and indirectly related to the reproductive prognosis of women. Information about the impact of this possible relationship between birth weight and ovarian follicular reserve may offer clinicians several possibilities for better dealing with conception and contraception planning for women throughout their reproductive life. Objectives. Primary Objective: To assess the impact of birth weight and weight for gestational age on ovarian follicular reserve in women older than 30 years. Secondary Objectives: To assess the impact of birth weight, weight for gestational age, longitudinal weight evolution, height and nutritional factors on the fecundity, parity, incidence of abortions and premature deliveries, regularity and characteristics of the menstrual cycles, and symptoms associated with declining ovarian activity. Methodology. Cross-sectional study nested in a cohort. Study population: Women born in 1978 in the municipality of Ribeirão Preto (SP). Study Subgroups: Small for Gestational AGE (SGA), Adequate for Gestational Age (AGA) and Large for Gestational Age (LGA) analyszed in the following groups: A (total number of patients included) and B (group of presumably healthy included patients with no confounding factors regarding reproductive potential). Sample size: 552 women (276 AGA, 138 SGA, and 138 LGA). Primary Outcome: Follicular Reserve estimated on the basis of serum levels of AMH. Secondary Outcomes: Fecundity rate, number of pregnancies, children, abortions and preterm deliveries, menstrual cycle pattern, symptoms related to the menstrual cycle and to the sexual sphere, and serum FSH, estradiol, inhibin B and activin A, B and AB levels

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA LARA, LUCIA ALVES; DOS SANTOS LIMA, MARIA LUCIA; ROMAO, GUSTAVO SALATA; FERRIANI, RUI ALBERTO; DE ALBUQUERQUE SALLES NAVARRO, PAULA ANDREA. Factors Related to Coital Frequency of Women in Their Thirties. JOURNAL OF SEX & MARITAL THERAPY, v. 42, n. 5, p. 403-412, . (13/16118-0)
LIMA, MARIA L. S.; ROMAO, GUSTAVO S.; BETTIOL, HELOISA; BARBIERI, MARCO ANTONIO; FERRIANI, RUI A.; NAVARRO, PAULA A.. Association of birth weight with functional ovarian reserve during menacme estimated by serum concentration of anti-Mullerian hormone. SCIENTIFIC REPORTS, v. 9, . (13/16118-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Maria Lucia dos Santos. Association between birth weight and functional ovarian reserve estimated through seric concentration of AMH: A nested cohort study of menacme women. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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