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Effect of beetroot (Beta vulgaris L .) by-products on oxidative stress of high-fat diet rats

Grant number: 13/18498-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2014
Effective date (End): December 31, 2014
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Caroline Dario Capitani
Grantee:Isabela Micheletti Lorizola
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil


Vegetables stalks and leaves have a significant amount of bioactive compounds, especially phenolic compounds that are waste during domestic and industrial processes. Beetroots (Beta vulgaris L.) byproducts (stalks, leaves, husks or bagasse) presented cytotoxic capacity and expressive ability in improving the response to oxidative stress in animals subjected to high-fat diet. Thus, this project aims to evaluate the effect of beetroot stalks and leaves on oxidative stress in animals subjected to high-fat diet. The leaves and stalks will be dehydrate in a conventional oven in order to simulate the domestic cooking process, and then be added to the animal (8% of total phenolic compounds). The animals (n = 30) will be divided into two groups (maintenance diet and high-fat diet) containning dehydrated stalks and leaves or ethanol extract of dehydrated stalks and leaves. At the end of the experiment (8 weeks), the animals will be sacrificed and blood and liver tissue will be used for the following analyzes: lipid profile, concentration of Malondialdehyde (MDA), plasma antioxidant activity by ORAC method, antioxidant activity of enzymes superoxide dismutase (SOD ), catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPx). The results will be compared between groups using analysis of variance (ANOVA) at a significance level of 5% probability.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LORIZOLA, ISABELA MICHELETTI; MIYAMOTO, JOSIANE ERICA; FIGUEIREDO VIEIRA, ANA LUIZA; SUMERE, BEATRIZ ROCCHETTI; NEVES BEZERRA, ROSANGELA MARIA; TORSONI, MARCIO ALBERTO; TORSONI, ADRIANA SOUZA; ROSTAGNO, MAURICIO ARIEL; MILANSKI, MARCIANE; CAPITANI, CAROLINE DARIO. Beet (Beta vulgaris L.) stalk and leaf supplementation changes the glucose homeostasis and inflammatory markers in the liver of mice exposed to a high-fat diet. FOOD CHEMISTRY: MOLECULAR SCIENCES, v. 2, p. 10-pg., . (13/04304-4, 13/18498-5, 16/24768-3, 15/15035-0)
LORIZOLA, ISABELA M.; FURLAN, CIBELE P. B.; PORTOVEDO, MARIANA; MILANSKI, MARCIANE; BOTELHO, PATRICIA B.; BEZERRA, ROSANGELA M. N.; SUMERE, BEATRIZ R.; ROSTAGNO, MAURICIO A.; CAPITANI, CAROLINE D.. Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice. NUTRIENTS, v. 10, n. 7, . (13/04304-4, 15/15035-0, 13/18498-5)

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