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Overall micro-RNA expression profile in human Sertoli cells (HSEC) after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Grant number: 13/12154-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2013
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Wellerson Rodrigo Scarano
Grantee:Mariana Antunes Ribeiro
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):15/16863-3 - Profile integration expression of microRNAs and mRNAs for reconstruction of gene regulatory networks in human Sertoli cells exposed to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD), BE.EP.DR


Infertility affects 10-15% of couples on reproductive age and male factor may be responsible for 30-50% of the cases. Male fertility and spermatogenesis process are directly related to the ability of Sertoli cells to produce factors associated with germ cells development. Only the Sertoli cells have receptors for FSH and testosterone, and therefore these cells are the major spermatogenesis regulators. Studies suggest that 60-70% male infertility cases are considered idiophatic, since the molecular mechanisms involved in spermatogenesis are still unknown. Recent studies report that regulatory RNA molecules encoded by the genome, such as microRNAs (miRNAs) can regulate testicular function during spermatogenesis and their altered expression may be involved with various factors of male infertility. miRNAs may play an important role in response to xenobiotics and chemical consequences to health, causing diseases. An important group of organic compounds with high toxic protencial are the dioxins, having as its most representative 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Experimental models of exposure (mice) demonstrated that TCDD causes low sperm count and delayed puberty. Thus, this study aims at correlating the action of TCDD compound in different doses and exposure times on the human Sertoli cells (in vitro) and its possible action in the expression profile of miRNAs. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, MARIANA A.; ESTILL, MOLLY S.; FERNANDEZ, GEYSSON J.; MORAES, LEONARDO N.; KRAWETZ, STEPHEN A.; SCARANO, WELLERSON R.. Integrative transcriptome and microRNome analysis identifies dysregulated pathways in human Sertoli cells exposed to TCDD. Toxicology, v. 409, p. 112-118, . (13/12154-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RIBEIRO, Mariana Antunes. Reconstruction of genetic regulatory networks in human Sertoli cells exposed to Tetrachlorodibenzo-p-dioxin (TCDD). 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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