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Prevalence of HTLV-1 and HTLV-2 among HIV-infected patients from an AIDS service of São Paulo

Grant number: 13/19775-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2013
Effective date (End): March 31, 2015
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Adele Caterino de Araújo
Grantee:Carlos Henrique Barreto Damião
Host Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The human T-cell lymphotropic viruses (HTLV-1, HTLV-2, and HIV) share the same routes of virus transmission and diverge in pathogeneses. HTLV-1 is the etiological agent of adult T-cell leukemia/lymphoma (ATL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM), HTLV-2 is not associated with any particular disease, and HIV is responsible for the global pandemic of AIDS. These viruses can infect the same individual and the coinfection can accelerate or retard the development of related diseases. It is known that HIV/HTLV-1 coinfection can either delay the start of antiretroviral therapy (ARV) or accelerate the development of AIDS, while HIV/HTLV-2 coinfection may delay the onset of AIDS. The prevalence rates of HIV/HTLV-1/2 co-infections vary according to geographic region and the study population. The present study aims to determine the prevalence of HIV/HTLV-1 and HIV/HTLV/2 coinfections in patients attended at an AIDS Reference Center of São Paulo (CRT-Aids), and to compare the performance of serological screening tests (enzyme immunoassays - EIA) and confirmatory assays [Western Blot (WB), immunochromatographic assay (INNOLIA) and the real time polymerase chain reaction (RT-PCR)] for HTLV-1/2 diagnosis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CATERINO-DE-ARAUJO, ADELE; SACCHI, CLAUDIO TAVARES; GONCALVES, MARIA GISELE; CAMPOS, KAROLINE RODRIGUES; MAGRI, MARIANA CAVALHEIRO; ALENCAR, WONG KUEN; SAO, GRP SURVEILLANCE DIAG HTLV. Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in Sao Paulo, Brazil. AIDS Research and Human Retroviruses, v. 31, n. 5, p. 543-549, . (13/19775-2, 12/51220-8)
CATERINO-DE-ARAUJO, ADELE; SACCHI, CLAUDIO TAVARES; GONCALVES, MARIA GISELE; CAMPOS, KAROLINE RODRIGUES; MAGRI, MARIANA CAVALHEIRO; ALENCAR, WONG KUEN; GRP SURVEILLANCE DIAG HTLV SAO. Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in Sao Paulo, Brazil. AIDS Research and Human Retroviruses, v. 31, n. 5, p. 7-pg., . (13/19775-2, 12/51220-8)
KAROLINE RODRIGUES CAMPOS; MARIA GISELE GONÇALVES; NADIA APARECIDA COSTA; ADELE CATERINO-DE-ARAUJO. Comparative performances of serologic and molecular assays for detecting human T lymphotropic virus type 1 and type 2 (HTLV-1 and HTLV-2) in patients infected with human immunodeficiency virus type 1 (HIV-1). Brazilian Journal of Infectious Diseases, v. 21, n. 3, p. 297-305, . (12/51220-8, 13/19775-2, 16/03654-0)

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