Scholarship 13/20302-1 - Dermatologia, Dermatite atópica - BV FAPESP
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Standardization of the technique for interleukin-31 (IL-31) mensuration by immunohistochemistry in healthy dog skin

Grant number: 13/20302-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: December 01, 2013
End date until: November 30, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Luiz Henrique de Araújo Machado
Grantee:Amanda Dias Tadeu
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Atopic dermatitis (AD) is a frequent disease that affects dogs of any breed or age that are predisposed to a genetic mutation that reduces both the homogeneity and the number of lipids and keratin composing the epidermal barrier. Common clinical signs are pruritus and inflammatory lesions, thus diminishing the life quality of the animals with AD. IL-31 carries the sensation of pruritus until the brain by linking to a specific receptor. The present study aims to standardize the technique for interleukin-31 (IL-31) mensuration by immunohistochemistry in healthy dog skin. All the animals used for this purpose will be free of any dermatological complaints and prevenient from clinical casuistic at the Veterinary hospital of UNESP - Botucatu. (AU)

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