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Immunomodulation and angiogenic activity of new thiazolidine compounds in wound healing process on MKR mice

Grant number: 13/23140-2
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): March 01, 2014
Effective date (End): August 31, 2014
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Dulcineia Saes Parra Abdalla
Grantee:Jacqueline Cavalcante Silva
Supervisor: Marcelo G. Bonini
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Illinois at Chicago (UIC), United States  
Associated to the scholarship:12/14360-6 - Investigation of the effects of new thiazolidinediones in animal model of metabolic syndrome., BP.MS


Preliminary results obtained in the Masters project "Investigation of new thiazolidine compounds effects in animal model of metabolic syndrome", demonstrated that this new thiazolidine compound, GQ-11, has in vivo immunomodulatory, anti-inflammatory and hypoglycemic effects, besides of angiogenic actions showed in previous in vitro studies of our group, what predicts a promising therapeutic strategy in wound healing, from homeostasis promotion at healing process. So, to expand this investigation, a collaboration between the Clinical Biochemistry Laboratory, supervised by Prof. Dulcineia Saes Parra Abdalla at the School of Pharmaceutical Sciences of University of São Paulo and the Cardiology and Pharmacology Laboratory, supervised by Prof. Marcelo Bonini, at University of Illinois at Chicago (UIC) was established to develop complementary studies to investigate the actions of the new thiazolidine compounds (GQ-11, GQ-02, GQ-177 and Lyso-7) on healing process by using MKR mice. (AU)

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