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Associations between vitamin D, osteocalcin, adipokines and markers of energy metabolism among Brazilian and American adolescents

Grant number: 13/15823-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): September 20, 2013
Effective date (End): December 19, 2013
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Lígia Araújo Martini
Grantee:Kelly Virecoulon Giudici
Supervisor: Connie M. Weaver
Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Purdue University, United States  
Associated to the scholarship:11/22768-2 - Relationship between fat mass and bone: metabolic interaction between vitamin D, vitamin D receptor genotype, osteocalcin and leptin in adolescentes, BP.DD


Adipokines such as adiponectin and leptin play, through hypothalamic modulation, an important role on bone formation, glucose homeostasis and satiety control. Leptin and osteocalcin genes are both controlled by vitamin D receptor. The effects of overweight and vitamin D deficiency at the bone mass of adolescents are not completely known, and substances such as leptin seem to have strong involvement in the regulation of their bone metabolism and glucose homeostasis. Objective: To investigate the relationship between serum vitamin D and osteocalcin with adipokines (leptin and adiponectin), biomarkers from energy metabolism (serum glucose, insulin, HOMA-IR) and nutritional status among Brazilian adolescents, and to integrate the results of the study conducted in Brazil with results obtained with an American population. Methods: This cross sectional study included 198 adolescents from 14 to 18 years old living in São Paulo, Brazil. Participants were interviewed by trained personnel and answered socioeconomic and demographic questionnaires, a 24-hour Food Recall, the International Physical Activity Questionnaire (IPAQ), and questions about sun exposure. Height and weight were measured in duplicate, as well as waist circumference. Blood collection after 12-hour fasting was done for biochemical analysis of: 25 hydroxyvitamin D, parathyroid hormone, glucose, insulin, carboxylated and non-carboxylated osteocalcin, leptin, adiponectin and lipid profile (total cholesterol, triglycerides, VLDL-c, LDL-c and HDL-c). Data from American adolescents come from the Camp Calcium, a summer camp from Purdue University designed to study calcium metabolism in adolescents, and from the GAPI (University of Georgia [UGA], Purdue University [PU] and Indiana University [IU]) trial. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIUDICI, KELLY VIRECOULON; KINDLER, JOSEPH M.; MARTIN, BERDINE R.; LAING, EMMA M.; MCCABE, GEORGE P.; MCCABE, LINDA D.; HAUSMAN, DOROTHY B.; MARTINI, LIGIA ARAUJO; LEWIS, RICHARD D.; WEAVER, CONNIE M.; et al. Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States. NUTRITION & METABOLISM, v. 14, . (13/15823-2)

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