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The effects of sleep restriction in an animal model of ischemic brain injury

Grant number: 13/14420-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2013
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Monica Levy Andersen
Grantee:Lenise Jihe Kim
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The stroke is a cardiovascular disease of high prevalence and incidence in the world population responsible for different comorbidities that often incapacitate the patients to return to their daily activities. Sleep quality has been identified as an important predictor or preconditioning factor for the occurrence of ischemic stroke. Thus, the aim of this study is to evaluate the effects of sleep restriction (SR) in rats subjected to transient middle cerebral artery occlusion (TMCAO), considered an experimental model of ischemic stroke. We will investigate the mortality rate, the neurological function and the ischemic lesions severity. Male 2 months-old Wistar rats will be utilized. The animals will be submitted to the SR protocol for 18 hours during 21 days previously to TMCAO protocol. The severity of ischemic lesions will be evaluated by the mortality rate, cellular proliferation and death rate, the infarct volume and the neurological function after 7 days of stroke recovery. We hope with the present project perform a translational approach that allows to better understand the role of sleep and its effects on recovery of ischemic lesions in stroke patients.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORGADINHO COELHO, F.; HIROTSU, C.; BITTENCOURT, L.; TUFIK, S.; LEVY ANDERSEN, M.. Is an intermediate chronotype a protective factor to obstructive sleep apnea?. Sleep Medicine, v. 16, p. 1-pg., . (98/14303-3, 13/14420-1)
KIM, LENISE JIHE; COELHO, FERNANDO MORGADINHO; HIROTSU, CAMILA; ARAUJO, PAULA; BITTENCOURT, LIA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Frequencies and Associations of Narcolepsy-Related Symptoms: A Cross-Sectional Study. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 11, n. 12, p. 1377-1384, . (14/10255-9, 14/15259-2, 13/14420-1)
KIM, LENISE JIHE; COELHO, FERNANDO MORGADINHO; ARAUJO, PAULA; TEDESCO, ROBERTO CARLOS; SOUZA, RODRIGO BARBOSA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Sleep restriction reduces the survival time and aggravates the neurological dysfunction and memory impairments in an animal model of cerebral hypoperfusion. Brain Research, v. 1644, p. 213-221, . (13/14420-1, 14/10255-9)
KIM, LENISE JIHE; COELHO, FERNANDO MORGADINHO; HIROTSU, CAMILA; BITTENCOURT, LIA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Is the chronotype associated with obstructive sleep apnea?. Sleep and Breathing, v. 19, n. 2, p. 645-651, . (13/14420-1)
MELLO-FUJITA, LUCIANE; KIM, LENISE JIHE; PALOMBINI, LUCIANA DE OLIVEIRA; RIZZI, CAMILA; TUFIK, SERGIO; ANDERSEN, MONICA LEVY; COELHO, FERNANDO MORGADINHO. Treatment of obstructive sleep apnea syndrome associated with stroke. Sleep Medicine, v. 16, n. 6, p. 691-696, . (13/14420-1, 98/14303-3)

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