Voltammetric sensors containing mesoporous Silica modified with gold nanoparticles and nitroheterocyclic compounds with antichagasic activity - Bioelectrochemical Applications.

Abstract

The negligible diseases (Chagas, Leishmaniasis and Malaria) still represent nowadays a major public health problem. The biological activity of the compounds with antichagasic properties is closely related to the free radicals action, which are derivative from the monoeletronic reduction of nitro groups in the heterocyclic compounds. The electrochemical behavior of three new compounds with antichagasic properties will be studied using voltammetric techniques (cyclic voltammetry, differential pulse and square wave). As working electrodes it will be used: glassy carbon electrode (GCE), to characterize the drug electrochemical behavior in solution (mixed and aprotic media) and the carbon paste electrode (CPE), previously modified by incorporation of the water insoluble nitro compounds in the carbon paste composition (using the solid state voltammetry). Both working electrodes will still be modified using mesoporous silica FDU-12, containing lignin and gold nanoparticles. From these studies and the experimental reducing potential values it will be possible to correlate the reducing potential of these compounds with their biological.