Comparison of the alterations found on magnetic resonance imaging in juvenile and adult-onset systemic Lupus erythematosus

Abstract

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by various clinical manifestations. Patients with Systemic Lupus Erythematosus (SLE) have structural brain alterations. It was found that many of these patients have cognitive disorders that may intensify according to duration of the disease. The evaluation of neuropsychiatric manifestations in SLE involves a series of laboratory and neuroimaging techniques, and Magnetic Resonance Imaging (MRI) is the most sensitive test to detect brain changes. Among these changes, the MRI is widely used to detect anatomical cerebral abnormalities, including cerebral and corpus callosum atrophy. The objective of this study is to analyze and compare the prevalence of cerebral atrophy and corpus callosum in juvenile and adult-onset SLE.