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Evaluation of genetic polymorphisms on progression to infection of patients mono-infected and co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV)

Grant number: 13/00643-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): October 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Maria Inês de Moura Campos Pardini
Grantee:Viviam Milanez Massolini
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The human vulnerability to HIV infection is not uniform, virological and host factors are determinants on the risk of transmission and natural progression of the infection.Polymorphisms of KIR genes combined with HLA class I alleles of the patient, are being associated with progressionof HIV infection. Several studies have been performed in mono-infected with HIV-1, but little is known about the relationship of these polymorphisms in coinfection HIV/HCV. The purpose of this study is to assess infection the progression by HIV in patients coinfected HIV/HCV, based on clinical parameters, laboratory and virological, correlating genetic polymorphisms the host (KIR combined HLA class I), which may be useful for elucidating the natural history of the disease.300 samples will be used to form 3 groups (Group 1: 100 HIV mono-infected (subtype B);Group 2: 100 mono-infected HCV (genotype 1);Group 3: 100 Co-Infected HIV-1 (subtype B)/HCV). Determinations of subtypes (HIV) and genotypes (HCV) will be held from plasma,using RT-PCR and sequencing. The definitions of the KIR gene polymorphisms will be determined by PCR-SSP, and HLA will be accomplished out by sequencing. Clinical and laboratory data, regarding the evolution of HIV infection , will be analyzed from the medical records of patients. Statistical tests of association, parametric and nonparametric tests, Kaplan-Meier, log-rank test and logistic regression will be used for evaluation of the parameters involved in the study.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MASSOLINI, Viviam Milanez. Avaliação de polimorfismos genéticos na progressão da infecção de pacientes monoinfectados e coinfectados com os Vírus da Imunodeficiência Humana (HIV) e Vírus da Hepatite C (VHC). 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.

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