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Longitudinal analysis of white and gray matter structural abnormalities in juvenil systemic lupus erythematosus

Grant number: 13/09480-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2013
Effective date (End): July 31, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Simone Appenzeller
Grantee:Aline Tamires Lapa
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP


Systemic lupus erythematosus (SLE is a multisistemic disease characterized por periods of activity and remission. Disease onset during childhood is observed in 15-20% of the patients. Childhood-onset SLE has a different sex distribution and a more severe disease with greater cummulative organ damage. Central nervous system (CNS) involvment is frequently observed in cSLE and often we observe a dissociacion between clinical and neuroimaging features. Several neuronal injury biomarkers have been described in sle, however there is still doubt if they are clinically useful. MRI studies have shown whit ematter abnormalities in cSLE however so far only a few studies have analyzed structural abnormalites longitudinally. This study has the objective to follow cSLE patients longitudinally and determine the rate of white and gray matter abnormalities and determine if they are related to the presence of S100b.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAPA, ALINE TAMIRES; POSTAL, MARIANA; SINICATO, NAILU ANGELICA; FERREIRA, WESLLEY GERALDO; BELLINI, BRUNA SIQUEIRA; FERNANDES, PAULA TEIXEIRA; RITTNER, LETICIA; MARINI, ROBERTO; CENDES, FERNANDO; APPENZELLER, SIMONE. Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis. ARTHRITIS & RHEUMATOLOGY, v. 68, n. 9, p. 2193-2199, . (13/01936-0, 11/03788-2, 08/02917-0, 13/09480-5, 13/07559-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LAPA, Aline Tamires. Longitudinal analysis of white and gray matter structural abnormalities in juvenil systemic lupus erythematosus. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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