Biomaterials in periodontal tissue regenerative medicine

Abstract

This proposal aims at obtaining assistance in carrying out a research exchange by the researcher Sonia Maria Malmonge, faculty researcher at the Undergraduate and Graduate Biomedical Engineering courses from Federal University of ABC, which aims to initiate collaborative activities and enable the interaction and exchange of experiences between two teams, one French and one Brazilian, through the knowledge of both parties in the development of bioresorbable polymers and hydrogels scaffolds for use in regenerative medicine of tissue damaged by periodontal diseases. The proponent develops research activities in biomedical devices with expertise in biocompatible materials, involving polymeric hydrogels and bioresorbable polymers and was invited to develop activities in collaboration with the team of Biomaterials and Biological Interfaces, coordinated by researcher Dr. Brigitte Grosgogeat, along one of the units of the Laboratory of Multimaterial and Interfaces (LMI), linked to the CNRS (URS 5615), University Claude Bernard Lyon 1. Periodontal disease is a disease of infectious origin which causes deterioration of the oral tissues, reaching a large part of the population, although some forms of periodontitis affect young individuals, chronic periodontitis affects mostly adults and the incidence increases with age. Thus, prevention and treatment of the injured tissues, caused by periodontal disease, as well as the regeneration of damaged structures are now the primary goals of studies in periodontology, Although advances have been achieved throughout the 20th century, grafting techniques employed only allow correction, without the regeneration of the periodontal apparatus. Tissue engineering in regenerative medicine presents itself as a promising alternative and, in this context, the search for devices that can be used in tissue engineering motivate the development of three-dimensional structures that enable modulation of the cell behavior and the regeneration of injured periodontal tissues. (AU)