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Influence of Aerobic Exercise on the Expression and Distribution of microRNAs in the Hippocampal Formation of Adult Rats

Grant number: 13/13725-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2013
Effective date (End): November 30, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Ricardo Mario Arida
Grantee:Jansen Fernandes
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated scholarship(s):15/09234-0 - Effects of voluntary exercise on spatial memory and BDNF-related miRNAs expression after traumatic brain injury, BE.EP.DR

Abstract

The scientific literature has extensively documented the beneficial effects of physical exercise on brain function. Physical exercise has the ability to improve the cognitive function, decrease age-related memory loss, delay the onset of neurodegenerative diseases, facilitate recovery after brain injury and improve depressive symptoms. MicroRNAs (miRNAs) are small, non-coding RNAs of approximately 23 nucleotides that act as potent silencers of gene expression by inducing translational repression or degradation of target mRNA. miRNAs regulate the expression of genes involved in several biological processes, such as cell cycle, apoptosis, and cell differentiation. These molecules are abundantly present in the adult brain and have a spatiotemporal expression pattern. The neurobiological role of these molecules in processes such as brain development, aging, injury, cognition and neurological disorders, has received more attention only in recent years. Considering the key role of this noncoding RNAs on post-transcriptional control of gene expression, and the positive influence that physical exercise promotes on brain function, the present study aims to investigate the effects of acute, short and long-term aerobic exercise on expression and distribution of miRNAs in the hippocampus of adult rats. The results of this study can help us to understand the complexity of the mechanisms underlying the exercise-induced improvement on brain function, and may contribute to identifying potential therapeutic targets for the treatment of several neurological diseases.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE ALMEIDA, ALEXANDRE APARECIDO; DA SILVA, SERGIO GOMES; LOPIM, GLAUBER MENEZES; CAMPOS, DIEGO VANNUCCI; FERNANDES, JANSEN; CABRAL, FRANCISCO ROMERO; ARIDA, RICARDO MARIO. Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy. Journal of Neuroscience Research, v. 96, n. 5, p. 911-920, . (13/12692-4, 14/00035-1, 13/13725-3, 11/50680-2)
FERNANDES, JANSEN; VIEIRA, ANDRE SCHWAMBACH; KRAMER-SOARES, JULIANA CARLOTA; DA SILVA, EDUARDO ALVES; LEE, KIL SUN; LOPES-CENDES, ISCIA; ARIDA, RICARDO MARIO. Hippocampal microRNA-mRNA regulatory network is affected by physical exercise. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1862, n. 8, p. 1711-1720, . (13/13725-3, 11/50680-2)
FERNANDES, JANSEN; KRAMER SOARES, JULIANA CARLOTA; ZACCARO DO AMARAL BALIEGO, LUIZ GUILHERME; ARIDA, RICARDO MARIO. A Single Bout of Resistance Exercise Improves Memory Consolidation and Increases the Expression of Synaptic Proteins in the Hippocampus. HIPPOCAMPUS, v. 26, n. 8, p. 1096-1103, . (13/13725-3)
FERNANDES, JANSEN; ARIDA, RICARDO MARIO; GOMEZ-PINILLA, FERNANDO. Physical exercise as an epigenetic modulator of brain plasticity and cognition. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 80, p. 443-456, . (13/12692-4, 15/09234-0, 13/13725-3)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.