Naproxen encapsulated in nanostructured lipid carriers for parenteral administration: preparation, characterization and pharmacological evaluation.

Abstract

Compounds anti-inflammatory drugs (NSAIDs) are widely used to combat inflammation, but often cause side effects which hinder the continued treatment. The use of carrier systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), aims to improve biopharmaceutical and pharmacological properties of the compounds in them interspersed. In this context, naproxen, an anti-inflammatory highly used in clinical medicine, presents a strong candidate for this type of entrainment, since it has low solubility and is therefore not used by parenteral routes which diminishes its potential application hospital. The tests used in this study aimed at the development of a formulation for parenteral administration of naproxen using the CLN. Evaluations will be done on the effectiveness of the formulation by molecular methods and in vivo tests and stability of the formulations will also be examined.