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Epidemiology of bacterial infections in patients with cystic fibrosis involving Achromobacter and Burkholderia cepacia complex bacteria

Grant number: 13/13455-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2013
Effective date (End): January 31, 2017
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Ana Lúcia da Costa Darini
Grantee:Carolina Paulino da Costa Capizzani
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):15/04615-5 - Elucidation of taxonomy and population structure of Achromobacter and Burkholderia strains deriving from CF patients of a public hospital from Brazil, BE.EP.DR


Cystic fibrosis (CF) is one of the fateful autossomal recessive illnesses most common at occidental world. Chronic infection of respiratory tract accounts for the high rate of morbidity and mortality of patients suffering from cystic fibrosis. Achromobacter and Burkholderia cepacia complex (BCC) bacteria are among the gram-negative non-fermenting (BGN-NF) more isolated from these patients. Due to phenotypic similarity between them, misidentifications are often reported, making essential molecular methods for identification. These pathogens are responsible for severe inflammation, with progressive decrease of lung function, and also show high resistance to multiple antibiotics It is a challenge to understand the epidemiology, ecology and clinical impact of human infection with Achromobacter, therefore it is extremely important to perform methods as molecular typing for increasing epidemiological knowledge of these species. The purpose of this work is to study Achromobacter and BCC bacteria, in CF patients being treated at the Hospital das Clínicas of the Ribeirão Preto Medical School of the University of São Paulo - USP (HCFMRP-USP) and Hospital das Clínicas of Medical Sciences School - UNICAMP (HCFCM-UNICAMP): identify BCC genomovares and investigate virulence genotypes; evaluate the antimicrobial susceptibility from isolates belonging to Achromobacter sp. and Burkholderia sp.; investigate possible genetic relationships among isolates of A. xylosoxidans and A. denitrificans, using macro restriction analysis of chromosomal DNA after Pulsed-field Gel electrophoresis; elucidate the taxonomy and epidemiology of isolates from Achromobacter sp. by Multilocus Sequence Typing (MLST). The results will be discussed with the medical team involved in order to provide life improved quality of these patients.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CACADOR, NATALIA CANDIDO; DA COSTA CAPIZZANI, CAROLINA PAULINO; MONTEIRO MARIN TORRES, LFDIA ALICE GOMES; GALETTI, RENATA; CIOFU, OANA; DA COSTA DARINI, ANA LTICIA; FLEFIBY, NIELS. Adaptation of Pseudomonas aeruginosa to the chronic phenotype by mutations in the algTmucABD operon in isolates from Brazilian cystic fibrosis patients. PLoS One, v. 13, n. 11, . (13/13455-6, 15/11728-0, 14/14494-8, 13/13358-0)
DA COSTA CAPIZZANI, C. P.; CACADOR, N. C.; TORRES, L. A. G. M. M.; TONANI, L.; VANDAMME, P.; DA COSTA DARINI, A. L.. Clinical and microbiological profile of chronic Burkholderia cepacia complex infections in a cystic fibrosis reference hospital in Brazil. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, v. 36, n. 11, p. 2263-2271, . (13/13455-6, 13/13358-0, 14/14494-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CAPIZZANI, Carolina Paulino da Costa. Epidemiology of bacterial infections in patients with cystic fibrosis involving Achromobacter and Burkholderia cepacia complex. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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