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Association of nutritional and inflammatory parameters with ventricular remodeling in patients with rheumatoid Arthritis

Grant number: 13/10894-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2013
Effective date (End): August 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Paula Schmidt Azevedo Gaiolla
Grantee:Karina Lie Utiaque Narimatsu
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects not only joints but also exhibits systemic manifestations, including fatigue, malnutrition, and other organs such as the heart. The pathophysiological mechanisms involved in RA injuries are multifactorial that include inflammatory mediators, oxidative stress and others. These mechanisms may be associated with heart disease. In fact, cardiovascular diseases increase mortality in more than 50% in patients with RA. Increased levels of inflammatory mediators are suggested to explain, in part, atherosclerosis and cardiovascular risk. Additionally, inflammation may be associated with cardiac remodeling, regardless of the vascular effects of atherosclerosis. However, the mechanisms involved in cardiac remodeling in patients with RA are still controversial. Studies have shown both cardiac hypertrophy and atrophy in patients with RA. However, these studies did not perform the complete assessment of nutritional status. Thus, the objective of this study is to evaluate whether inflammation and nutritional aspects, in patients with RA, are associated with cardiac remodeling. Therefore, we will study from 70 to 100 patients with RA, who undergo nutritional assessment (dietary recall, bioelectrical impedance analysis, handgrip test and densitometry X-ray absorbance), echocardiography (cardiac structural and functional variables) and evaluation of inflammation by zymography (metalloproteases 2 and 9).

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