The prostate is a gland of the male genital system, found only in mammals, whose main function is to produce part of seminal fluid. Prostatic lesions occur most commonly in middle-aged men and prostate cancer (PCa) is the most commonly diagnosed among men in America and in the Western Europe. The development of PCa is a slow process and can result from accumulation of damages promoted for decades, involving, among other factors, genetic and epigenetic alterations that disrupt the molecular mechanisms that control cell proliferation, differentiation and apoptosis. With the increase in the number of men diagnosed with PCa, it's increasing the amount of new therapeutic alternatives in order to reduce the progress of the disease. Recent findings suggest that human tumors have epigenetic changes such as unregulated expression of microRNAs, molecules considered new oncogenes or tumor suppressors, which may be useful as biomarkers for tumor diagnosis, prognosis and staging. Considering the importance of further studies focusing on PCa biology and the important action of some microRNAs in PCa, this study aims to investigate the expression of the oncogenic microRNAs miR-125b, miR-221 and miR-222 in prostate tumor LNCaP cells exposed to the extracellular matrix component fibronectin.
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