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Post-transcriptional regulation of PHB gene by RNA-binding proteins and microRNAs in human melanoma

Grant number: 13/11721-0
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): January 02, 2014
Effective date (End): January 01, 2015
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Roger Chammas
Grantee:Priscila Daniele Ramos Cirilo
Supervisor abroad: Luiz Otavio Ferraz Penalva
Home Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Research place: University of Texas Health Science Center at Houston (UTHealth), United States  
Associated to the scholarship:11/18337-6 - Functional characterization of 3'UTR region of PHB gene in human melanomas, BP.PD


Cutaneous melanoma is one epithelial tumor originates in melanocytes. This tumor represents 4% of malignant neoplasms of skin and it is considered an important public health problem because of its high progression to metastasis and treatment resistance. Previous studies of our group revealed the accumulation of prohibitin (PHB) in cell lines of human melanoma after treatment with cisplatin. PHB is an evolutionarily conserved chaperone involved in various cellular processes, including proliferation and cell cycle. Our group also showed that rare alleles of SNP rs6917 at 3'UTR of PHB gene (3'UTR-PHB) is a risk factor for the development of melanoma in patients living in regions with high UVB index. Transcripts with long 3'UTR are putative targets of post-transcriptional regulation, such as a PHB isoform. RNA binding proteins (RBPs) and microRNAs (miRNAs) are key mediators of post-transcriptional regulation and aberrant action of these factors can lead to tumorigenesis. However, post-transcriptional regulation of PHB in melanoma has not been described. In this project, will be the characterized RBPs and miRNAs that regulates the 3'UTR-PHB non-melanoma, parental and human melanoma cell line transformed with the 3'UTR-C (wild type allele) and 3'UTR-PHB-T (rare allele). After functional characterization, the post-transcriptional regulators of PHB, could be useful as putative targets of melanoma development and/or chemoresistance. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAMOS CIRILO, PRISCILA DANIELE; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; SILVA CORREA, BRUNA RENATA; QIAO, MEI; FURUYA, TATIANE KATSUE; CHAMMAS, ROGER; FERRAZ PENALVA, LUIZ OTAVIO. MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1. BMC CANCER, v. 17, NOV 10 2017. Web of Science Citations: 12.

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