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Evaluation of colonization and infection by multiresistant bacteria in patients with chronic kidney disease in conservative treatment

Grant number: 13/09075-3
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2013
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Nursing - Infectious Diseases Nursing
Principal Investigator:Dulce Aparecida Barbosa
Grantee:Cibele Grothe Esmanhoto
Host Institution: Escola Paulista de Enfermagem (EPE). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Infection is the major cause of morbidity and the second most frequent cause of mortality in patients with failure chronic renal disease. The S. aureus, coagulase negative Staphylococcus and Enterococcus spp are the main colonizing agents and causing infections in this population, as well as producing Klebsiella pneumoniae carbapenemase (KPC). Considering the possibility of concomitant infection and colonization by S. aureus methilicin resistance (MRSA), S. aureus with intermediate resistance to vancomycin (VISA), vancomycin-resistant Enterococcus (VRE) and KPC, we are motivated in this study. Method: a cohort study in the Department of Dialysis and Transplantation of Unifesp which will be included 300 patients in conservative treatment,. To determine the prevalence of colonization will be conducted surveillance of microorganisms: MRSA and VISA through collection of nasal samples from all patients. Surveillance of VRE and KPC through stool samples or rectal swab. The isolation, identification, culture, antimicrobial susceptibility testing, molecular typing and other molecular tests will be conducted in accordance with the standards of the Clinical and Laboratory Standards Institute (CLSI). Patients will be followed by a period of six months to record the morbid complications such as infection and causes of hospitalization and death. (AU)

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