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Obtainment and characterization of calcium carbonate nanotubes aiming the preparation of bioactive surfaces

Grant number: 13/12615-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Ana Paula Ramos
Grantee:Camila Bussola Tovani
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Tube-like structures have attracted scientists' attention due to their peculiar features tailored by geometry and composition that combined can origins materials with high surface area and high mechanic strength. These materials can be applied in several fields like microelectronics and biomedicine. For the last, it is recommended to get information about the toxicity, biocompatibility, and bioactivity of the materials. In this sense, materials formed by calcium carbonates and phosphates which are minerals abundant in natural systems and biocompatible can be used for biomedical applications. The aim of the present project is the preparation and characterization of CaCO3 nanotubes. The bioactivity of this material will be tested in colloidal dispersions as well as in films deposited on titanium surfaces using a layer-by-layer (LbL) polyelectrolyte matrix. The LbL films will be formed using biopolymers like oppositely charged polysaccharides. In the first stage, the CaCO3 nanotubes will grow in a simple way by using porous polycarbonate membranes as templates. The characterization of the composition of the samples will be carried out by using Fourier transform infrared spectroscopy (FTIR). The morphology will be studied by using scanning electron microscopy (SEM) and transmission electron microscopy. The crystallinity will be investigated by x-ray diffraction. After the deposition of the LbL films, the titanium surface will be characterized with relation to its composition, morphology, topography, and surface energy by FTIR, SEM, atomic force microscopy, and contact angle measures, respectively. To the bioactivity evaluation, the dispersion of the nanotubes, as well as the modified surfaces, will be exposed to a solution that simulates the ionic composition of the human plasma. It is expected at the end of the project, the comprehend of the parameters that affect the formation of the nanotubes and hybrid films, and how they influence in the bioactivity of the titanium surfaces. (AU)

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VEICULO: TITULO (DATA)
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TOVANI, C. B.; ZANCANELA, D. C.; FARIA, A. N.; CIANCAGLINI, P.; RAMOS, A. P.. Bio-inspired synthesis of hybrid tube-like structures based on CaCO3 and type I-collagen. RSC ADVANCES, v. 6, n. 93, p. 90509-90515, . (13/12615-0, 12/20946-3, 14/24249-0)
TOVANI, C. B.; FARIA, A. N.; CIANCAGLINI, P.; RAMOS, A. P.. Collagen-supported CaCO3 cylindrical particles enhance Ti bioactivity. SURFACE & COATINGS TECHNOLOGY, v. 358, p. 858-864, . (13/12615-0, 17/08892-9, 14/24249-0, 16/21236-0, 12/20946-3)

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