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Antibacterial potenctial of mushrooms Lentinus edodes, Agaricus bisporus e Agaricus blazei with evidence of Helicobater pylori

Grant number: 13/10454-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2013
Effective date (End): July 31, 2014
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Taís Maria Bauab
Grantee:Victor Artemio Almeida de Lucena
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The search for new antimicrobial agents is very important, since the bacteria have a high potential for genetic recombination, leading to an increase in strains resistant to existing antimicrobial drugs. In this context, the mushrooms may be an alternative, because the chemical constituents of these extracts exhibit activity against various pathogenic isolates used in folk medicine. Among the species of greatest interest are the Agaricus blazei (sun mushroom), Agaricus bisporus (champignon) and Lentinus edodes (shiitake). Helicobacter pylori are responsible for gastrointestinal diseases of importance to public health, such as ulcers, gastritis, and malignant tumors. The most common treatment in the control of this microorganism is not effective. Mushrooms appear as an alternative to new research in this field, and may eventually be used to develop new herbal or even as this adjuvant treatment. There are several methods to determine antimicrobial activity, including microdilution. Being widely used mainly because of its sensitivity and small use of reagents and samples, enabling a larger number of tests increasing the reliability of the results. Continuing the study of our research group this study aims to determine the potential anti-H. pylori of mushrooms, instigated by the possibility of finding an alternative for the treatment of this microorganism given its importance in public health. (AU)

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