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Influence of zinc supplementation on cardiac remodeling after myocardial infarction

Grant number: 13/06862-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2013
Effective date (End): March 31, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Leonardo Antonio Mamede Zornoff
Grantee:Andréa de Freitas Gonçalves Della Ripa
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Heart failure is responsible for a large number of hospitalizations worldwide. The main causes of this disease are myocardial ischemia and systemic arterial hypertension. Among the ischemic changes, can emphasize the acute myocardial infarction (MI). After MI may be changes in ventricular architecture complex, involving both the infarcted region as the non-infarcted. Recently, these adaptations came to be studied with the name or cardiac ventricular remodeling. Due to the large socio-economic impact and high mortality rates, it becomes important to identify factors that modulate the process of ventricular remodeling, such as zinc. Zinc is divalent metal, essential for the activity of several enzymes such as angiotensin converting enzyme, superoxide dismutase and extracellular matrix metalloproteinases (MMPs). Furthermore, the metal structure has a fundamental role in cell membranes, and stabilization of the structures of RNA, DNA and ribosomes. Currently, experimental and clinical evidence shows that serum zinc is decreased in heart failure. This reduction can interfere with the activity of metalloproteinases, with oxidative stress and consequently the inflammatory process. However, the influence of zinc supplementation on cardiac remodeling after acute myocardial infarction has not been studied.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GONCALVES, ANDREA F.; POLEGATO, BERTHA F.; FERNANDES, ANA ANGELICA; ISHIKAWA, LARISSA LUMI; OKOSHI, KATASHI; BAZAN, SILMEIA G. Z.; MINICUCCI, MARCOS F.; AZEVEDO, PAULA S.; IKOMA, MAURA R.; PENITENTI, MARCIMARA; et al. Zinc Supplementation Attenuates Cardiac Remodeling After Experimental Myocardial Infarction. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 50, n. 1, p. 353-362, . (12/14500-2, 13/06862-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RIPA, Andréa de Freitas Gonçalves Della. Influence of zinc supplementation on cardiac remodeling after myocardial infarction. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.

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