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Nanomaterials and cell membrane interaction: understanding the molecular interaction phenomena

Grant number: 13/14400-0
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): August 01, 2013
Effective date (End): December 31, 2013
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal researcher:Valtencir Zucolotto
Grantee:Juliana Cancino Bernardi
Supervisor abroad: Kenneth Dawson
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Research place: University College Dublin, Ireland  
Associated to the scholarship:12/03570-0 - Nanomaterials applied to nanomedicine: development of membrane models and in vitro studies for evaluation the toxicity., BP.PD

Abstract

Understanding the binding and exchange behavior of nanomaterials interacting with cells is a challenge. As example, several indirect methods (as uptake and life cycle) are available for the determination of such phenomena. However, in some cases, these methods exhibit limited sensitivity or selectivity. Knowing that nanoparticle "see" the cell membrane in their first contact with cells, the aim of this study is to elucidate the nanoparticle interaction with the cell membrane (cell membranes with natural lipids and proteins extracted from different cell lines) at the molecular level. In this case, cell membranes will be isolated by ultracentrifugal sedimentation and the interaction with cationic and anionic nanoparticles (fluorescently labeled) will be observed by confocal fluorescence, isotherm titration calorimetry, transmission electron microscopy and/or flow cytometry. (AU)

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