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Studies on the intermolecular enantioselective Heck-Matsuda reaction of complex acyclic olefins and synthetic applications.

Grant number: 13/10639-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2013
Effective date (End): February 28, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Carlos Roque Duarte Correia
Grantee:Carlise Frota
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


One of the big challenges in organic chemistry is the enantioselective synthesis which main objective is to prepared enantiomeric enriched or pure organic compounds. Another challenge in this field is to make such processes feasible and practical in the organic laboratory, as many available methods require special conditions, such as exclusion of oxygen, use of toxic ligands, low scale and anhydrous conditions.In view of the considerable academic and industrial interest in such methods, this research proposal focus on the efficient and practical synthesis of a range of aryl lactonas in an enantiomeric fashion, having as its main step the enantioselective Heck-Matsuda reaction employing alkene diols. These substrates will also be used in a more extensive study concerning the regioselectivity of these Heck-Matsuda reactions. The expected arylated products from these reactions are outstanding chiral building blocks, which can be used in the synthesis of several bioactive molecules.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FROTA, Carlise. Heck-Matsuda arylation in trisubstituted olefins: methodological study and application in meso-hexestrol synthesis. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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