One of the big challenges in organic chemistry is the enantioselective synthesis which main objective is to prepared enantiomeric enriched or pure organic compounds. Another challenge in this field is to make such processes feasible and practical in the organic laboratory, as many available methods require special conditions, such as exclusion of oxygen, use of toxic ligands, low scale and anhydrous conditions.In view of the considerable academic and industrial interest in such methods, this research proposal focus on the efficient and practical synthesis of a range of aryl lactonas in an enantiomeric fashion, having as its main step the enantioselective Heck-Matsuda reaction employing alkene diols. These substrates will also be used in a more extensive study concerning the regioselectivity of these Heck-Matsuda reactions. The expected arylated products from these reactions are outstanding chiral building blocks, which can be used in the synthesis of several bioactive molecules.
News published in Agência FAPESP Newsletter about the scholarship: