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Analysis of miRNAs involved in regulation of MMP2 and MMP9 and its implication of this regulators and regulating the process of cell migration and invasion of the prostate adenocarcinoma

Grant number: 13/02515-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2013
Effective date (End): June 30, 2014
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Sabrina Thalita dos Reis Faria
Grantee:Gustavo Noboru Cavallari Inoue
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Prostate cancer displays a peculiar biology with a high prevalence and low incidence clinic. The discovery and use of tumor markers have positively influenced early detection, diagnosis and staging of a number of neoplasms. The search and identification of new markers in PCa has been reason research in several laboratories, including ours (LIM 55), and promising results have been reported. Among the promising markers are the genes belonging to the family of matrix metalloproteinase. Matrix metalloproteinase (MMP) are proteins belonging to a family of about thirty endoproteinases or proteolytic enzymes that degrade several extracellular matrix components. Recently, a new class of regulatory molecules were described, micro RNA. miRNA is endogenous small molecule, non-protein coding, single-stranded, consisting of 19-25 nucleotides which belong to a new class of potent post-transcriptional regulators of gene expression. In our previous work group identified changes in gene expression MMP-2, MMP-9, TIMP-1, TIMP-2, RECK, MMP-14, and moreover, an association of expression with classical prognosis factors of prostate cancer. Knowing the importance of these genes in prostate carcinogenesis, we decided to evaluate the role of microRNAs in regulating these genes and the implication of this regulation in cell migration and invasion. We emphasize that there are no studies in the literature involving MMP and miRNAs in prostate carcinoma, demonstrating the originality of this study. (AU)

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