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Interaction of electrical fields with cardiac myocytes: calculation of induced transmembrane potential with electromagnetic model

Grant number: 13/05441-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2013
Effective date (End): January 31, 2015
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Jose Wilson Magalhaes Bassani
Grantee:Hugo Fernando Maia Milan
Host Institution: Faculdade de Engenharia Elétrica e de Computação (FEEC). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The process of excitation of cardiac cells by external electrical field (E) presents physiological differences when compared with stimulation by using the voltage-clamp technique. The stimulatory current applied during voltage-clamp produces an homogeneous variation of the transmembrane potential (deltaVm), while the application of E produces an heterogeneous deltaVm. For the application of E to be effective in generating an action potential, event which precedes the cellular contraction, it is necessary that deltaVm reach a threshold value (deltaVL) in a critical area of the membrane. Assuming deltaVL independent on the direction of application of the E, it is possible to estimate the average E independently on the direction (Eind). The recent models to calculate deltaVL and Eind are based on analytical models that consider the cardiac myocyte as a prolate spheroid. It has been demonstrated that the difference between the values of deltaVm obtained with models that describe the real geometry of the cell and those describing the cell with a regular geometric form can be as high as 20%. Therefore, the solution would be to model the isolated ventricular cardiac cell of rats in neonatal, infant and adult developmental ages, exposed to E, by using the finite elements method, therefore based in a more realistic cellular geometry, to compute deltaVL and Eind. These results will be compared with those obtained with the analytical model of prolate spheroid as well as with the experimental results.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HUGO FERNANDO MAIA MILAN; ROSANA ALMADA BASSANI; JOSÉ WILSON MAGALHÃES BASSANI. Testing electrode suitability for field stimulation of high-threshold biological preparations. Res. Biomed. Eng., v. 31, n. 3, p. 273-276, . (13/05441-5)
MILAN, HUGO F. M.; BASSANI, ROSANA A.; SANTOS, LUIZ E. C.; ALMEIDA, ANTONIO C. G.; BASSANI, JOSE W. M.. Accuracy of electromagnetic models to estimate cardiomyocyte membrane polarization. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, v. 57, n. 12, p. 2617-2627, . (13/05441-5)
MILAN, HUGO F. M.; ALMAZLOUM, AHMAD A.; BASSANI, ROSANA A.; BASSANI, JOSE W. M.. Membrane polarization at the excitation threshold induced by external electric fields in cardiomyocytes of rats at different developmental stages. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, v. N/A, p. 11-pg., . (13/05441-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MILAN, Hugo Fernando Maia. Comparison of models to estimate the maximal transmembrane electrical potential variation induced by electrical fields in isolated cardiomyocytes of rats of different ages. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Elétrica e de Computação Campinas, SP.

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