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Type 3 collagen and Metalloproteinase 9 polymorfism as a risk factor for urinary incontinence in pregnant women with gestational diabetes mellitus

Grant number: 12/25207-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Marilza Vieira Cunha Rudge
Grantee:Ana Paula Machado de Almeida
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Gestational Diabetes Mellitus, characterized by glucose intolerance of variable intensity, firstly detected during pregnancy, has been identified as a risk factor for urinary incontinence. The collagen has a essencial role for urinary continence. The literature shows that in urinary incontinence occurrence, the gene expression of proteins was altered as well as increased activity of MMPs. The type 1 and 3 collagen polymorphism also have been investigated because it influences the occurrence of urinary incontinence. This paper is appropriate because there is a necessity of new investigations about possible influencing factors in the urinary continence and integrity of pelvic floor muscle. This paper aims at analyzing the relationship between type 3 collagen and metalloproteinase 9 polymorphism and urinary incontinence in women with Gestational Diabetes Mellitus. We will analyze approximately 300 women, selected through manipulation from the Prenatal Clinic. Women who gave birth between 2009 and 2012, as well as pregnant women between the 34th and 38th week of gestation by the time of collection and that meet the inclusion criteria will be included in the study. The collection will include the use of an evaluation form, a questionnaire about quality of life for women with urinary incontinence, a questionnaire to quantify and qualify the urinary loss and another questionnaire about sexual response in pregnancy, anthropometric measurements and collection of saliva samples. The statistical analysis as well as the tests to compare variables and groups will be chosen according to the results, characteristics and behavior of the variables. The analysis of retrospectively data will be made separately and together.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CUNHA RUDGE, CIBELE VIEIRA; PARANHOS CALDERON, IRACEMA DE MATTOS; MACHADO DE ALMEIDA, ANA PAULA; PICULO, FERNANDA; CUNHA RUDGE, MARILZA VIEIRA; PASCON BARBOSA, ANGELICA MERCIA. Definição de escores e versão em português brasileiro do Inventário da Resposta Sexual na Gestação (PSRI). Revista Brasileira de Ginecologia e Obstetrícia, v. 40, n. 6, p. 322-331, . (12/25207-4, 12/15577-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALMEIDA, Ana Paula Machado de. Polimorfismo do colágeno tipo 3 e da metaloproteinase 9 como fator de risco para a incontinência em muheres com diabete mellitus gestacional. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.

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