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Biocompatible composites based on amphiphilic copolymers and hydroxyapatite

Grant number: 12/24821-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2013
Effective date (End): February 02, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Maria Isabel Felisberti
Grantee:Lívia Mesquita Dias Loiola
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:10/17804-7 - Polymeric composites, AP.TEM
Associated scholarship(s):14/24383-9 - Block copolymers of polyphosphoesters and poly(L-lactic acid) for biomedical applications, BE.EP.DD


This project seeks to develop biocompatible composites from amphiphilic copolymers and particles of hydroxyapatite, both potentially biocompatible, with outlined properties that enable their application in the biomedical area, for example, in the controlled release of drugs, in the constitution of tissues, and so on. The synthesis of amphiphilic copolymers is made from commercial polyethers such as poly(ethylene glycol) (subject to crystallization) and copolymers of ethylene and propylene oxides (amorphous); and polyesters synthesized through ring-opening polymerization of the cyclic monomers L-lactide (resulting in crystallizable PLLA) and lactide (resulting in amorphous PLA), resulting in a polymer matrix with pre-set physicochemical and mechanical properties. Thus, some distinct and novel polymeric materials will be obtained, with both varied chemical composition and molecular weight, to be applied in the final production of composites. Hydroxyapatite particles on the nanometer scale will be synthesized and then treated superficially in order to stabilize them during the process of dispersion in the organic matrix. The composites will be obtained by the casting technique and will be characterized by the morphology and by the mechanical and physicochemical properties. The study of biocompatible composite is an academic and also technological interest, especially in the areas of biomedical application, such as tissue engineering, drug carriers, and so on. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOIOLA, LIVIA M. D.; CORTEZ TORNELLO, PABLO R.; ABRAHAM, GUSTAVO A.; FELISBERTI, MARIA I.. Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour. RSC ADVANCES, v. 7, n. 1, p. 161-172, . (15/25406-5, 12/24821-0, 10/17804-7)
LOIOLA, LIVIA M. D.; DE FARIAS, MARCELO A.; PORTUGAL, RODRIGO V.; FELISBERTI, MARIA I.. Amphiphilic polylactide-poly(ethylene oxide)-poly(propylene oxide) block copolymers: Self-assembly behavior and cell affinity. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, v. 56, n. 19, p. 2203-2213, . (10/17804-7, 12/24821-0, 15/25406-5)
LOIOLA, LIVIA M. D.; MAS, BRUNA A.; DUEK, ELIANA A. R.; FELISBERTI, MARIA I.. Amphiphilic multiblock copolymers of PLLA, PEO and PPO blocks: Synthesis, properties and cell affinity. EUROPEAN POLYMER JOURNAL, v. 68, n. SI, p. 618-629, . (10/17804-7, 12/24821-0)
DE ALMEIDA, PAULA; DIAS LOIOLA, LIVIA MESQUITA; PETZHOLD, CESAR LIBERATO; FELISBERTI, MARIA ISABEL. Sucrose Methacrylate-Based Amphiphilic Block Copolymers. MACROMOLECULAR CHEMISTRY AND PHYSICS, v. 218, n. 4, . (12/24821-0, 13/09277-5, 15/25406-5, 10/17804-7, 16/03394-8)
LOIOLA, LIVIA M. D.; FASCE, LAURA A.; DA SILVA, LAURA C. E.; GONCALVES, MARIA C.; FRONTINI, PATRICIA M.; FELISBERTI, MARIA I.. Thermal and mechanical properties of nanocomposites based on a PLLA-b-PEO-b-PLLA triblock copolymer and nanohydroxyapatite. Journal of Applied Polymer Science, v. 133, n. 44, . (10/17804-7, 12/24821-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LOIOLA, Lívia Mesquita Dias. Amphiphilic block copolymers: synthesis, characterization and application in biomaterials. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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