Advanced search
Start date

Total synthesis of a sesquiterpene

Grant number: 13/05179-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2013
Effective date (End): May 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Luiz Fernando da Silva Júnior
Grantee:Fernando Caldiron Rezende
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


A new route for the racemic synthesis of a sesquiterpene using as a key step a ring contraction reaction promoted by iodine(III) developed in our group is presented. In ten steps from a commercially available starting material - 5-methoxy-1-tetralone - we will be able to reach a natural product whose synthesis was not described so far. The natural product, as well as advanced intermediated, will be evaluated toward anti-tumor activity in the laboratory of Prof. J. E. de Carvalho (UNICAMP). (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: