Advanced search
Start date

Nitric oxide releasing iron oxide nanoparticles

Grant number: 13/04288-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2013
Effective date (End): December 31, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Amedea Barozzi Seabra
Grantee:Ana Carolina Ferraz Ferrarini
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil


The endogenous-found molecule nitric oxide (NO) is involved in several important physiological processes, such as the control of vasodilation of blood vessels, cell communication, immune response, and wound healing. As NO is a small size molecule, devoid of charge, and relatively lipophilic, it diffuses easily in the biological medium crossing most physiologic barriers, without the presence of cell membrane receptors. In the biological medium, NO is unstable, and it can readily react with biomolecules, such as hemoglobin, leading to its inactivation. Moreover, NO controls several physiological functions, deficiencies in its production and/or transport, or its inactivation, result in pathophysiological states. Thus, there is a great effort in the development of NO-releasing materials, which can be used in several biomedical applications. A promising strategy that has been used to facilitate the therapeutic use of NO is based on the combination of metallic nanoparticles with NO donor molecules, such as S-nitrosothiols (RSNOs). Iron oxide magnetic nanoparticles (Fe3O4) are known for their biocompatibility and are used as vehicles for controlled drug release, in biological systems. In this context, the objective of this project is the preparation of functionalized iron oxide as NO donor vehicle. The development of this nanostructured material involves the synthesis of NO-releasing nanoparticles, their physicochemical characterization, kinetic studies of NO release, and toxicological evaluation of the prepared materials. This project is aimed to create a biocompatible material capable to carry and delivering NO, with great potential to use in biomedical applications. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: